Invasion Precedes Tumor Mass Formation in a Malignant Brain Tumor Model of Genetically Modified Neural Stem Cells
نویسندگان
چکیده
منابع مشابه
Invasion precedes tumor mass formation in a malignant brain tumor model of genetically modified neural stem cells.
Invasiveness, cellular atypia, and proliferation are hallmarks of malignant gliomas. To effectively target each of these characteristics, it is important to understand their sequence during tumorigenesis. However, because most gliomas are diagnosed at an advanced stage, the chronology of gliomagenesis milestones is not well understood. The aim of the present study was to determine the onset of ...
متن کاملAn overview of therapeutic approaches to brain tumor stem cells
Primary and secondary malignant central nervous system (CNS) tumors are devastating invasive tumors able to give rise to many kinds of differentiated tumor cells. Glioblastoma multiform (GBM), is the most malignant brain tumor, in which its growth and persistence depend on cancer stem cells with enhanced DNA damage repair program that also induces recurrence and resists current chemo- and radi...
متن کاملDrosophila neural stem cells in brain development and tumor formation.
Neuroblasts, the neural stem cells in Drosophila, generate the complex neural structure of the central nervous system. Significant progress has been made in understanding the mechanisms regulating the self-renewal, proliferation, and differentiation in Drosophila neuroblast lineages. Deregulation of these mechanisms can lead to severe developmental defects and the formation of malignant brain t...
متن کاملDiagnosis of brain tumor using PNN neural networks
Cells grow and then need a very neat method to create new cells that work properly to maintain the health of the body. When the ability to control the growth of the cells is lost, they are unconsidered and often divided without order. Exemplified cells form a tissue mass called the tumor. In fact, brain tumors are abnormal and uncontrolled cell proliferations. Segmentation methods are used in b...
متن کاملBiological Use of Neural Stem Cells for Brain Tumor Therapy
Neural stem cells (NSCs) have the tremendous potential to migrate to areas of pathology in the central nervous system (CNS) (1,2). When implanted into diseased or injured CNS, NSCs can travel great distances and engraft within discrete areas as well as diffuse neuronal abnormalities (1,2). Engraftment is often followed by integration into the local neural milieu, accompanied by stable gene expr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Neoplasia
سال: 2011
ISSN: 1476-5586
DOI: 10.1593/neo.11624